Effects of low-dose oral micronised progesterone on sleep, psychological distress, and breast development in transgender individuals undergoing feminising hormone therapy: a prospective controlled study

BJ Nolan; AS Frydman; SY Leemaqz; M Carroll; M Grossmann; JD Zajac; AS Cheung

Journal article

Effects of low-dose oral micronised progesterone on sleep, psychological distress, and breast development in transgender individuals undergoing feminising hormone therapy: a prospective controlled study

BJ Nolan, AS Frydman, SY Leemaqz, M Carroll, M Grossmann, JD Zajac, AS Cheung

Endocrine Connections | Published : 2022

DOI: 10.1530/EC-22-0170

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Abstract

Objective: The role of micronised progesterone in hormone regimens for transgender individuals undergoing feminising hormone therapy remains uncertain. We aimed to determine the effect of oral micronised progesterone on sleep quality, psychological distress, and breast development in transgender individuals undergoing feminising hormone therapy. Design: Prospective case–control study. Twenty-three transgender individuals on stable oestradiol treatment newly commencing 100 mg oral progesterone (n = 23) and controls continuing standard care (n = 19) were assessed over 3 months. Methods: Pittsburgh Sleep Quality Index (PSQI), Kessler psychological distress scale (K10), and Tanner stage to asses..

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University of Melbourne Researchers

Mathis Grossmann Author

Jeffrey Zajac Author

Ada Cheung Author

Brendan Nolan Author

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Awarded by Bayer HealthCare

Funding Acknowledgements

B J N is a recipient of an Australian Government National Health and Medical Research Council Postgraduate Scholarship (no. 2003939). A S C is supported by a National Health and Medical Research Council Early Career Fellowship (no. 1143333) and Investigator Grant (no. 2008956).